Eletone IngredientsElectronic Ingredients
In view of the associated dangers of long-term permanent use with these pharmacological active substances, there is a need for alternative products with similar anti-inflammatory and barrier-free characteristics, which can be used without restriction and without taking into account any particular hazard. A number of over-the-counter (OTC) ingredients such as oat flakes and kerosene as well as anti-inflammatory moisturisers (medical product creams) have proven their effectiveness with minor side effects in the correction of dermal barriers and symptomatic alleviation of steroidal diseases.
Tcute calcineurinic inhibitors (TCIs; Acrolimus Ointment Protopic®; Protopic®; Dimecrolimus Cream/Elidel®) are second-line therapy for the rapid and discontinuous adjuvant therapy of mild to profound AD in non-immunosuppressed adult and pediatric patients who have not responded sufficiently to other topical AD procedures or are unsuitable for use in AD. The 10-12 thyroid clots do not cause dermal athrophy or impede colagen production, allowing their use in the facial, cervical, and intertriginal areas.
To date, this has remained theoretically valid and is mainly due to the mode of effect of the medicine, experimental results from animals and some individual cases of lymphomas and melanoma in TCI treating people. Recently, medicinal product lotions (Table 1), which are non-steroidal active ingredients with softening, anti-inflammatory and antiseptic effects, have been launched on the market to address irritable skin conditions, to address functional disorders of the subcutaneous layer and to restrict the possible long-term use of TCS and CCIs.
It is a hydrophilic creme with botyrospermum parakii (shea tree), lycyrrhetinic acids (liquorice), vitis vinifera essence, Bisabolol (German chamomile), thyaluronic acids and cocopheryl acetateate ( vitamine E). It is said to have moisturising, anti-inflammatory and antioxidative effects. It also contains telmestein, which blocks elastomerase, colagenase and metalloproteinase matrices, thus preventing peptide degradation.
? contains lipide compounds that imitate the natural cutaneous barriers (triglycerides, phosphorlipids and squalene) together with the anti-inflammatory drug marabinoid N-palmitoylethanolamine (N-PEA), an end-ogenous fat glomeramide directed against the peroxisomal proliferator-activated protein acceptor alphah (PPAR-?). Other added ingredients such as cleansed tapioca, virgin olive water, glycerine, pentylene glycol, plant oils and hydrated ecithin have moisturizing and softening properties.
17,18 Eletone has a high level of lipids found in an external hydrolipidic layer (Technology?) disperse in petroleum, treated waters and petroleum. Hylatopic Plus is a soothing creme and lather containing Theobroma graniflorum seeds butters ( a nourishing buttermilk derived from the fruits of a Brazilian cupuaçu tree), glycerol, thyaluronic anhydride, Dimethicon, petrolatum as well as cocopheryl acetate monomer (vitamin E).
21 All medicinal product lotions are indicated for the management of various types of dermatosis such as AD, hypersensitive skin and radiant skin associated with signs of pruritus, burn and soreness. AD explains the disordered proinflammatory barriers by nonsensical modifications in the FLG coding genes and subsequently affects the proinflammatory pathway such as an increase in the IL-1 zytokine profiles in the stratum cordneum.
FLG disfunction or disappearance strongly affects kitinocyte adherence, increases TEWL and causes disregulation of dermal pH, leading to enhanced dermal translucency. The importance of an uncompromising dermal obstacle for the improvement of inflamed states cannot therefore be overemphasised and should play an important role both in the therapy of patients with chronic diseases and in long-term illness control.
Importantly, despite the recognized contribution of a faulty barrier of impermeability to epidermis [i.e. FLG-mutation, diminished LMPs such as kallikreine and cathelicidine (LL-37) of humans tissues and dehydration of dermatitis, immunological anomalies such as T-helper typ 2 (Th2) cytokines[i. Evidence indicates that the evolution of IBD is likely to be due to basic immunodeficiency regulation, as the main cause and subsequent malfunction may be secondarily.
Kolloidal oat flour has a long tradition of benefits in dermatological diseases associated with itching and irritations as it can calm and defend irritated skins. In 2003, oat meal became an OTC monographic component. Subtle particulates spread across the surface of the epidermis to create a protecting, exclusive moisture layer that delays moisture depletion and hydrates to enhance the moisture level.
In addition, oat flakeaponins help to dissolve soil, oils and sebum excretions that can normalise the pH of the epidermis. Like mentioned before, ceramic amides - a familiy of lipide molecule consisting of Sphingosin and a fat acids present in high concentration in the membranes of tissues in the Stratum Cordneum - are an integral part of the regular-Stratum Corneum and serve to preserve the integrity of the dermal wall.
They are important hydrophilic macromolecules in extracyte spaces, connecting nucleocytes and forming a watertight bound. Ceramine-defective epidermis is characterized by elevated levels of PD, dehydration and improved impermeability to environment stimuli and Allergens. In a recent trial, the mechanism of changes in ceramic in atopic lesions was found to be due to both T1 (accentuate) and T2 (attenuate) cytotoxins such as IL-4 and IL-6, as well as to IL-4 and IL-6 interacting with IFN (interferon frequency transduction ) - ? and TNF (tumour necrosis factors ) - ?, which affect the ceramic level in stripes.
This further confirms that immunodysregulation in AD has a variety of pathological consequences on the human body. Recent moisturizers/topical dermal treatment formulations (Table 2), which aim to enhance malfunction of the epiderermal membrane by filling up the amount of ceramic in the dermis - with ceramic and pseudoceramic formulations that mimic the body's own physical membrane - are a key pillar of adjuvant treatment for AD sufferers.
It is known that appropriate moisturization treatment can decrease the incidence of flare and restrict the need for TCS or a TCI, which is likely a consequence of the re-establishment of accessibility functions, as well as the re-establishment of correct permability functions and elevated level of AMP. A further trial of a ceramide-dominant physiological lipid-based barrier-free reparative enzyme (TriCeram®) in 24 pediatric patients also treated with TCS or a TCI for the treatment of refractory AD showed an enhancement, whereby the use of a ceramide-dominant moisturizing cream can significantly improve the signs and symptoms of AD in comparison to conventional agents.51 TriCeram was stopped by the company and is no longer available on the medical device shelves.
Evoceram® (a prescribing device) is composed of a unique blend of ceramic, ester and fat acid (in a 3:1:1 ratio) which imitates the natural components of the human body and has similar activity to a medium active topically active corticosteroid. EpiCeram® was evaluated in a five-day, investigator-blinded, randomized study with fluoresticasone (Cutivate®) creme in 121 individuals with moderately to severely AD. EpiCeram showed lower levels of marked adverse events, less itching, and better sleeping patterns 14 and 28 consecutive days following treatment.
A recent trial showed an increase in dehydration and dehydration levels and a decrease in PDWL through the use of a new moisturiser (Cetaphil Restoraderm Body Moisturzier; CRM) containing FLG degradation agents [Natural Moisturizing factor (NMF)], a ceramic progenitor pseudoceramid 5 or N-(2-hydroxyhexadecanoyl) sphinganine und niacinamid (vitamin B3) at 4 weeks versus the non-treated areas.
Specifically, a significantly higher serum concentration in the skin with CRM was found in the corneum stratum in comparison to the controls and a tendency towards an elevated moisture concentration was noticed. Drug-prescribed medicinal product lotions are not considered pharmaceuticals, but rather medicinal products that have obtained FDA approval of 510(k) on the basis of a proven reduced total swelling (TEWL), a less comprehensive approval procedure that is focused on drug resistance and less on effectiveness.
Every appliance creme contains ingredients with suggested moisturising, anti-inflammatory and antipruritic qualities that can be useful as an adjuvant or corrective treatment for dermatitis and thus help reduce the use of TCS or TCIs. Disfunction of the ppidermal wall is a result of a combined effect of genes affected by immunodeficiency regulation and normal structure protein.
Dermatitis requires TCS and/or TCI therapy to manage strokes, but also appropriate and appropriate moisturisation to alleviate textural dysfunctions and inadequate moisture. Since TCS can cause long-term adverse reactions and some individuals are involved in the TCI alert ingame, non-drug option such as OTC and/or ethical medicinal product cream with known moisturising, anti-inflammatory and antipruritic effects are important excipients that can be used on a day-to-day basis without the risk associated with pharmaceuticals.
An examination of current treatments for acute and chronic acute respiratory diseases. Heeck IM, Rouwen TJ, Timmer-de Mik L, et al. T Topical Kortikosteroide in neurodermatitis and the risks of developing glucoma and cataract. Effectiveness versus systematic effect of six topically active compounds in the therapy of neurodermatitis in children. The effect of subcutaneous absorbtion of hydracortisone on epinocortical reactivity in babies with serious dermatological diseases.
Shellfish HM, Lee JY, Kuo KW, et al. Degradation of streptococci intracellular lipids and functional barriers anomalies after long-term topical steroids. Long-lasting effectiveness and security of the Pimecrolimuscreme 1% with long-term application (up to 26 weeks) for the treatment of children with Neurodermitis.
Oakenfield LF, Eichenfield AW, Aucky, Boguniewicz, et al. Safety and effectiveness of ASM 981 creme 1% in the therapy of minor and moderately severe neurodermatitis in pediatric and adolescent patients. Low level of systematic absorbtion and good tolerance of Dimecrolimus, given as 1% Elidel creme in babies with adult skin disease - a multi-center, 3-week, open-label trial.
The use of topically active correticosteroids and topically active calcineurin Inhibitors for the therapy of thin and delicate areas of thin skins with epithelial inflammation. Thai Qi and Salgo R. Malignancy concern of recent calculation urine inhibitors for neurodermatitis: facts and disputes. Emergent medication for neurodermatitis. Experts say emerg drug. Effectiveness of a lipid-based carrier formula in moderately to severely paediatric moderately to severely acute paediatric acute respiratory distress.
Y Drugermatol. Electone®[instruction leaflet]. Abnormal anodic barriers in the patogenesis of Kontaktdermatitis. CM Mack Correa, Nebus J. Management of neurodermatitis patients: the roles of émollientotherapy. Hauttherapie-Brief. 2001 Dec;6(13):3-5. Nakatsuji T. Gallo RL. Mikrobial symbol ism with the congenital immunity system of the epidermis.
Faults of filaggrin-like protein in lesions and non-lesionsions of lesions of adult skins. Eichenfield LF, Ellis CN, Mancini AJ, et al. A. D.: Updating the D ermatological and Epidemiological Dermatology. Epidermal barriers and cutting sensitisation in the case of optic atopy. Cuo IH, Yoshida T, De Benedetto A, et al. The cutaneous congenital immunologic answer in neurodermatitis patient.
Effect of Petrolatum on the texture and functioning of the stratum cordneum. Marmur E. moisturizers: The real thing and the advantages for the epidermis. Connection between expidermal lipoogenesis and the cutaneous functioning of the barriers. The Miller DW, Koch SB, Yentzer BA, et al. A non-prescription moisturizing cream is as clinical as it is clinical and less expensive than prescribed oral barriers in the management of pediatric eczema: a gerandomised study.
Y Drugermatol. JJ Emer, Frankel A, Sohn A, et al. A comparative bi-lateral trial with 1% dimecrolimus creme and a topically applied medicinal product creme in the management of neurodermatitis sufferers. Y Drugermatol. Novel methods of restoration of impaired impermeability of the ppidermal barrier: Hautbarriere Reparaturcremes. for Nair B; expert panel for the review of cosmetic ingredients.
Fowler J, Draelos ZD, et al. slade HB, Fowler J, Draelos ZD, et al. evaluated the effectiveness of a novel protective skin blocker creme. Fowler J, Reece BT, et al. Slade HB, Reece BT, et al. Medical security assessment of a novel protective skin-crème. A 3-in-1 dam wash cloth impregnated with Dimethicon 3% versus aqueous solution and pH-neutral detergent for the prevention and treatment of incontinence-associated dermatitis: a randomised control study.
Y Drug Skin Care. Y Drug Skin Care. Biomann L, Woolery-Lloyd H, Friedman A. "Natural" ingredients in cosmetics Dermatologie. Y Drug Skin Care. E, Yoshida N, Sugiura A, et al. ÂTh1 Accentuate zytokines, but ÂTh2 zytokines dampen ceramic acid formation in the corneum of humans of epidermal equivalent: an implications for the impaired skin barriers in neurodermatitis.
Marginal barriers of the skin: Franke A, son A, Patel RV, et al. Comparative bi-lateral trial of 1% trimecrolimus creme and a ceramide-hyaluronic ester mousse in the therapy of neurodermatitis sufferers. Y Drugermatol. Chamberin SL, Kao J, Frieden IJ, et al. Ceramide-dominant barriers reparative lipids relieve children's parasitic dermatitis: changes in barriers indicate a significant level of clinical outcome.
A. Epiceram for the management of acute respiratory atitis. Drug today (Barc). Case study for the evaluation of a new cosmetic creme for the cutaneous barriers for the therapy of neurodermatitis. Y Drugermatol. Improvement of the dermal barriers in neurodermatitis sufferers with a new moisturizing creme containing a ceramic forerunner.
Aquaporine: an initiation into a crucial element in the moisture management mechanisms of the human body. Use of a plasticizer as a steroid preservative in the prophylaxis of light to medium neurodermatitis in infants. As a steroid-saving concomitant therapeutic measure in the management of patients with chronic forms ofsoriasis.
Crimalt R, Mengeaud V, Cambazard F, et al. The steroid-saving effect of emulsion client treatment in babies with neurodermatitis: a randomised control trial.