What is EpiceramEpiceram? What is Epiceram?
It was developed for the treatment of neurodermatitis, a type of eczema. EpiCeram's latest tweets (@EpiCeram_CRSBE).
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CERAGENIX STARTS PAEDIATRIC STUDY FOR EPICERAM
At Ceragenix Pharmaceuticals, we have started recruiting enrollment in a multi-center children's trial to evaluate the effectiveness of EpiCeram in medium to serious neurodermatitis or Eczema in comparison to Cutivate, a generally administered medium-strength esteroid. One half of the infants are treated with EpiCeram, the other half are treated with the hormone for four weeks.
Epiceram is intended to establish whether it can be as potent as a medium-strength ester both in the restoration of a healthy dermal wall, as assessed by transepidermal dehydration, and in the treatment of the signs and complaints associated with the disease. In April, Ceragenix obtained FDA regulatory approvals for the marketing of EpiCeram sold on prescription for the improvement of the dry complexion and for the relief and treatment of burns and pruritus associated with various types of dermatoses, which include neurodermatitis, skin-irritant contact dermatitis, radiated dermatitis and other dry dermatological diseases by preserving a wet surrounding of wounds and skins.
EpiCeram® - what is it?
EpiCeram® - what is it? Epoceram® Abulsion is a formula for the restoration of barriers that is only available on demand. Provides a one-of-a-kind cure for the treatment of neurodermatitis and sweet itch. EpirusCeram® has been designed on the basis of research carried out by the Elias-lab. For many years, our research group has been working to uncover the means by which the epidermis stops moisture from leaking from the human organism - its transmission bar.
Years ago, our lab uncovered the core principal behind the dermal barrier: lipid (or fat), which forms multi-layered membrane and encloses each individual within the most outer layer of dermal tissue (the so-called stringum corneum). Multilayers of fat diaphragms encircle multilayers of "dead" dermal tissue to create the superficial layer of our dermis and a high-redundancy water-repellent film.
If you would like to learn more about how the dermal barriers are created, register and get our free brochure "Primer On The Skin Barrier". Click here. Soon we and others found that an uncommon category of lipid, ceramide, which has been thought to occur only in cerebral tissues, is also the most common type of lipide in striptease.
For this reason, many dermatological treatments have been formulated containing either naturally occurring or, more generally, synthetically formulated forms of cermamides. Vitamides - large, intricate organics - make up about half of all lipid by molecule and a full 5% of the overall mass of the stratum core.
But soon afterwards we found that the other two lipid (cholesterol and free fats ) were also needed for the barriers. Only if we provide all three lipid substances together will the dermis normally cure after an attack, e.g. after we have removed external cell membranes with tape or washed the dermis with hard soap ( or detergent ).
The use of a product containing only Ceramide actually did cause further damage and the healing of the complexion was slow. It was the same if we had only used our own fat or our own diet. Healing of the wounded obstruction was more slow than usual when one lipid category was given without the other two.
Usually the 3 lipid keys are present in the membrane of the Stratum Corneum - i. e. blood lipids, free fat alcohols, free fat alcohols and free esters - with an identical number of molecule of each category and form a mole ration of 1:1:1:1. The supply of the damaged dermis with a mix of the 3 lipid in a mole proportion of 1:1:1:1 permitted a natural curing.
Soon afterwards we found that we can help the epidermis cure even more quickly by increasing the proportion of one of the three lipids to a 3:1:1:1 proportion. Whether it' s ceramide, lipids, cholesterol, etc., it could be the triple increase of the fat content in the mix to speed it up.
This 3:1:1:1 relationship was known as the "optimal molecular ratio" for the restoration of dermal barriers. Evoceram® has an optimum molecular proportions of dermal barriers, with ceramic being the dominant type of lipide. This was the finding of the optimum molecular proportions that formed the foundation for the EpiCeram® emulsions for the therapy of neurodermatitis.
Both we and other researchers had found that although the skins of neurodermatitis are defective in all three types of fat, the levels of ceramide decrease overproportionally. EpiCeram® was thus formed with ceramic as the dominant compound in order to achieve an optimum mole ration of 3 (ceramic): 1 (cholesterol): 1 (fatty acids) in the lipide emulsions.
A further essential characteristic of EpiCeram is that it re-establishes the natural level of acids in the dermis, the so-called "acid mantle". Normally the complexion is very sour. While the inside of the human organism is guarded tightly in the pH zone (~pH. 7. 4), the outer layer of the human organism is usually kept in the pH zone (pH~5.0). What is known as the "acid mantle" is discarded in the case of epithelial atitis, in which the pH of the epidermis rises to a more balanced level.
EpiCeram® - unlike most other dermatological treatments - is strongly sour in order to re-establish the protective film. The restoration of the pH value of the pH of the skins can give an important extra impulse for the thickness of the penetrability barriers. In neurodermatitis, this is particularly important because the proliferation of staph. ureus on both dermal lesion and often on non-involved dermis is an almost universally characteristic of this condition and is strongly associated with PD.
Adding several other useful constituents to the EpiCeram® formula. EpiCeram®, for example, also contains kerosene, lanolin and glycerine, which protects the epidermis and at the same time gives it a considerable moisturising effect. There are many product on the open road claiming to fix the obstacle, but few provide evidence of this. On behalf of EpiCeram®, several trials have proven its effectiveness in the therapy of neurodermatitis (see 1, 2, 3).
In fact, it has been shown to be efficient in treating even the most serious types of sclerosis. EpiCeram® has been shown to inhibit recurrence ("rebound flares") and side effect when used in conjunction with immunosuppressive treatments such as topically active steroids.
Whilst there are many other kinds of drugs on the table or under investigation to treat the neurodermatitis inflammatory disease, none of these other drugs addresses the basic neurodermatitis barriers disorder. In addition, worldwide trials are ongoing to evaluate the effectiveness of EpiCeram - not only in treating but also in preventing the onset of other hypersensitivity diseases such as asthma and rhinitis.
A recent trial has shown that EpiCeram was able to delay the progression of infant allergy to foods. Isn' EpiCeram just an inexpensive moisturiser? Clearly, EpiCeram is not just another moisturiser. In order to fully comprehend this, it is important to comprehend how the human race deals with those that contain "physiological" lipid substances - those found in the human organism - and those that are not.
Cholesterol, free fats and ceramides are all produced in the dermis; they are physiological lipids. What are they? Crude petrolatum is a by-product of burning fossils; its long-chain hydrocarbon is not naturally or physiologically for the epidermis. Both of these kinds of fats have very different properties when used on the face. Non-physiological lipid forms a layer on the outer layer of the epidermis.
On the contrary, physiological lipids, which are naturally for the epidermis, penetrate the stratum corneum till they arrive at the live cytoplasm. They take up these tissues, pack them into their "delivery vans" - a small organic cell known as the lamella epidermis - and drive them back into the corneum where they organise themselves to build its waterproof membrane.
If these physiological lipid substances are used in the correct proportions (1:1:1:1 or 3:1:1:1), they can build standard laminar membranous structure and thus restore the barriers. When they are present in the incorrect proportion (e.g. in a formula containing only ceramides), they do not produce standard diaphragms and the barriers may even leak.